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Kidney Transplant


Kidney transplant research aims to prolong the life of the recipient and the implanted kidney, balancing the risks and benefits of treatments and procedures, as well as increasing organ donation. Investigation includes strategies to match recipients and donors, testing immunosuppressive medications, living donor and deceased donor kidneys, and consequences of transplant tourism. 

Publications and Presentations


  • Barbour S, Gill JS. (2015). Advances in the understanding of complement mediated glomerular disease: implications for recurrence in the transplant setting. American journal of transplantation. 15(2): 312-9 
  • Cassidy, H, Slyne, J, O'Kelly, P, Traynor, C, Conlon, PJ, Johnston, O, Slattery, C, Ryan, MP, McMorrow, T. (2015). Urinary biomarkers of chronic allograft nephropathy. Proteomics Clinical Applications, 9(5-6), 574-585.
  • Cole, EH, Nickerson, P, Campbell, P, Yetzer, K, Lahaie, N, Zaltzman, J, Gill, JS. (2015). The Canadian Kidney Paired Donation Program: A National Program to Increase Living Donor Transplantation. Transplantation, 99(5), 985-990.
  • Garg AX, Nevis IF, McArthur E, Sontrop JM, Koval JJ, Lam NN, Hildebrand AM, Reese PP, Storsley L, Gill JS, Segev DL. (2015). Gestational hypertension and preeclampsia in living kidney donors. New England Journal of Medicine. 372(2):124-33.
  • Gill, J, Dong, JH. (2015). Population Income and Longitudinal Trends in Living Kidney Donation in the United States. Journal of the American Society of Nephrology. 26(1), 201-207.
  • Gill, JS, Knoll, GA, Humar, A. (2015). BK Virus Prophylaxis With Levofloxacin Reply. Jama-Journal of the American Medical Association. 313(11) 1165-1166.
  • Lentine, KL, Gill, J, Axelrod, D. (2015). Functional Status Metrics in Kidney Transplantation: Implications for Patients, Programs,  ,Policy Makers. American Journal of Kidney Diseases, 66(5), 738-741.
  • Levin, A, Muller, E, Alrukhaimi, M, Naicker, S, Tibbel, A. (2015). Transplant commercialism and organ trafficking: The Declaration of Istanbul with special relevance to disadvantaged populations living with kidney disease. Clinical Nephrology, 83, S85-S89.
  • Rose, C, Schaeffner, E, Frei, U, Gill, J, Gill, JS. (2015). A Lifetime of Allograft Function with Kidneys from Older Donors. Journal of the American Society of Nephrology, 26(10), 2483-2493.
  • Tong, A, Ralph, AF, Chapman, JR, Wong, G, Gill, JS, Josephson, MA, Craig, JC. (2015). Focus Group Study of Public Opinion About Paying Living Kidney Donors in Australia. Clinical Journal of the American Society of Nephrology, 10(7), 1217-1226.
  • Wright, AJ, Gill, JS. (2015). Kidney Transplantation in HIV-Infected Recipients: Encouraging Outcomes, but Registry Data Are No Longer Enough. Journal of the American Society of Nephrology, 26(9), 2070-2071.
  • Blydt-Hansen, T, Boyarsky, B, Chow, E, Cockfield, S, Cole, E, Cypel, M, Gill, J, Goldberg, A, Goulet, M, Hartell, D, Humar, A, Husain, S, Keshavjee, S, Kiberd, B, Kim, J, Knoll, G, Kramer, A, Kucirka, L, Kumar, D, Kutsogiannis, J, Lien, D, Nagendran, J, Nickerson, P, Paraskevas, S, Renner, E, Segev, D, Singer, L, Trpkovski, J, West, L, Wright, L, Young, K, Wor, CCIRD. (2014). Guidance on the Use of Increased Infectious Risk Donors for Organ Transplantation. Transplantation, 98(4), 365-369.
  • Delmonico F, Chapman J, Fung J, Danovitch G, Levin A, Capron A, Busuttil R, OConnell P. (2014). Open letter to Xi Jinping, President of the People’s Republic of China:  China’s fight against corruption in organ transplantation. Transplantion Journal. 97 (8), pp 1-2
  • Delmonico, FL, Capron, AM, Danovitch, GM, Levin, A, O'Connell, PJ. (2014). Organ transplantation in China-not yet a new era. Lancet. 384(9945), 741-741.
  • Gill J, Dong J, Gill J. (2014). Population income and longitudinal trends in living kidney donation in the United States.  J Am Soc Nephrol. 
  • Gill, J, Dong, J, Eng, M, Landsberg, D, Gill, JS. (2014). Pulsatile Perfusion Reduces the Risk of Delayed Graft Function in Deceased Donor Kidney Transplants, Irrespective of Donor Type and Cold Ischemic Time. Transplantation. 97(6), 668-674.
  • Gill, JS, Hendren, E, Dong, JH, Johnston, O, Gill, J. (2014). Differential Association of Body Mass Index with Access to Kidney Transplantation in Men and Women. Clinical Journal of the American Society of Nephrology. 9(5), 951-959.
  • Gill, JS, Klarenbach S, Barnieh L, Caulfield T, Knoll G, Levin A, Cole EH. (2014). Financial Incentives to Increase Canadian Organ donation:  Quick Fix or Fallacy? AJKD. 63(1), 133-40.
  • Gill, JS, Morris, R. (2014). Assessing Kidney Function in Transplant Recipients: Time to Work Together and Address the Most Relevant Questions. American Journal of Kidney Diseases. 64(5), 818-818.
  • Gill, JS, Tonelli, M. (2014). Outcomes After Kidney Donation In Reply. Jama-Journal of the American Medical Association. 312(1) 95-96.
  • Gill, JS, Tonelli, M. (2014). Understanding Rare Adverse Outcomes Following Living Kidney Donation. Jama-Journal of the American Medical Association. 311(6) 577-578.
  • Gunther, OP, Shin, H, Ng, RT, McMaster, WR, McManus, BM, Keown, PA, Tebbutt, SJ, Le Cao, KA. (2014). Novel Multivariate Methods for Integration of Genomics and Proteomics Data: Applications in a Kidney Transplant Rejection Study. Omics-a Journal of Integrative Biology. 18(11), 682-695.
  • Knoll, GA, Humar, A, Fergusson, D, Johnston, O, House, AA, Kim, SJ, Ramsay, T, Chasse, M, Pang, XL, Zaltzman, J, Cockfield, S, Cantarovich, M, Karpinski, M, Lebel, L, Gill, JS. (2014). Levofloxacin for BK Virus Prophylaxis Following Kidney Transplantation A Randomized Clinical Trial. Jama-Journal of the American Medical Association, 312(20), 2106-2114.
  • Shannon, CP, Balshaw, R, Ng, RT, Wilson-McManus, JE, Keown, P, McMaster, R, McManus, BM, Landsberg, D, Isbel, NM, Knoll, G, Tebbutt, SJ. (2014). Two-Stage, In Silico Deconvolution of the Lymphocyte Compartment of the Peripheral Whole Blood Transcriptome in the Context of Acute Kidney Allograft Rejection. Plos One, 9(4).
  • Tong, A, Ralph, A, Chapman, JR, Gill, JS, Josephson, MA, Hanson, CS, Wong, G, Craig, JC. (2014). Public Attitudes  ,Beliefs About Living Kidney Donation: Focus Group Study. Transplantation, 97(10), 977-985.
  • Barnieh, L, Gill, JS, Klarenbach, S, Manns, BJ. (2013). The Cost-Effectiveness of Using Payment to Increase Living Donor Kidneys for Transplantation. Clinical Journal of the American Society of Nephrology. 8(12), 2165-2173.
  • Cohen Freue GV, Meredith A, Smith D, Bergman A, Sasaki M, Lam KK, Hollander Z, Opushneva N, Takhar M, Lin D, Wilson-McManus J, Balshaw R, Keown PA, Borchers CH, McManus B, Ng RT, McMaster R, for the Biomarkers in Transplantation and the NCE CECR Prevention of Organ Failure Centre of Excellence Teams. (2013). Computational biomarker pipeline from discovery to clinical implementation: plasma proteomic biomarkers for cardiac transplantation. PLoS Comput. Biol. 2013 Apr 4;9:e1002963.
  • Danovitch, GM, Chapman, J, Capron, AM, Levin, A, Abbud, M, Al Mousawi, M, Bennett, W, Budiani-Saberi, D, Couser, W, Dittmer, I, Jha, V, Lavee, J, Martin, D, Masri, M, Naicker, S, Takahara, S, Tibell, A, Shaheen, F, Anantharaman, V, Delmonico, FL. (2013). Organ Trafficking and Transplant Tourism: The Role of Global Professional Ethical Standards-The 2008 Declaration of Istanbul. Transplantation. 95(11), 1306-1312.
  • Gill JS, Schaeffner E, Chadban S, Dong J, Rose C, Johnston O and Gill J. Quantification of the early risk of death in elderly kidney transplant recipients. Am J Transplant. 2013 Feb; 13(2):427-432.
  • Gill, J, Dong, J, Rose, C, Johnston, O, Landsberg, D. (2013). The Effect of Race and Income on Living Kidney Donation in the United States. Journal of the American Society of Nephrology. 24(11) 1872-1879.
  • Hollander Z, Chen V, Sidhu K, Lin D, Ng RT, Balshaw R, Cohen-Freue GV, Ignaszewski A, Imai C, Kaan A, Tebbutt SJ, Wilson-McManus JE, McMaster RW, Keown PA, McManus BM, for the NCE CECR PROOF Centre of Excellence. (2013). Predicting acute cardiac rejection from donor heart and pre-transplant recipient blood gene expression. The Journal of Heart and Lung Transplantation. 32(2):259-65.
  • Humar, A, Gill, J, Johnston, O, Fergusson, D, House, AA, Lebel, L, Cockfield, S, Kim, SJ, Zaltzman, J, Cantarovich, M, Karpinski, M, Ramsay, T, Knoll, GA. (2013). Quinolone prophylaxis for the prevention of BK virus infection in kidney transplantation: study protocol for a randomized controlled trial. Trials, 14.
  • Johnston O, Rose C, Gill JS. Risks and benefits of preemptive second kidney transplantation. Transplantation. 2013 Mar; 95:705-710.
  • Keown, PA. (2013). Predicting long-term outcome in renal transplantation. Kidney International, 84(4), 650-652.
  • Lin, D, Freue, GC, Hollander, Z, Mancini, GBJ, Sasaki, M, Mui, A, Wilson-McManus, J, Ignaszewski, A, Imai, C, Meredith, A, Balshaw, R, Ng, RT, Keown, PA, McMaster, WR, Carere, R, Webb, JG, McManus, BM, Biomarkers Transplantation, T, Ctr Excellence, C. (2013). Plasma protein biosignatures for detection of cardiac allograft vasculopathy. Journal of Heart  ,Lung Transplantation, 32(7), 723-733.
  • Perl, J, Dong, J, Rose, C, Jassal, SV, Gill, JS. (2013). IS DIALYSIS MODALITY A FACTOR IN THE SURVIVAL OF PATIENTS INITIATING DIALYSIS AFTER KIDNEY TRANSPLANT FAILURE?. Peritoneal Dialysis International, 33(6), 618-628.
  • Su, GCW, Greanya, ED, Partovi, N, Yoshida, EM, Shapiro, RJ, Levy, RD. (2013). Assessing Medication Adherence in Solid-Organ Transplant Recipients. Experimental  ,Clinical Transplantation, 11(6), 475-481.
  • Tait, BD, Susal, C, Gebel, HM, Nickerson, PW, Zachary, AA, Claas, FHJ, Reed, EF, Bray, RA, Campbell, P, Chapman, JR, Coates, PT, Colvin, RB, Cozzi, E, Doxiadis, IIN, Fuggle, SV, Gill, J, Glotz, D, Lachmann, N, Mohanakumar, T, Suciu-Foca, N, Sumitran-Holgersson, S, Tanabe, K, Taylor, CJ, Tyan, DB, Webster, A, Zeevi, A, Opelz, G. (2013). Consensus Guidelines on the Testing and Clinical Management Issues Associated With HLA  and Non-HLA Antibodies in Transplantation. Transplantation, 95(1), 19-47.
  • Abecassis M, Bridges ND, Clancy CJ, Dew MA, Eldadah B, Englesbe MJ, Flessner MF, Frank JC, Friedewald J, Gill J, Gries C, Halter JB, Hartmann EL, Hazzard WR, Horne FM, Hosenpud J, Jacobson P, Kasiske BL, Lake J, Loomba R, Malani PN, Moore TM, Murray A, Nguyen MH, Powe NR, Reese PP, Reynolds H, Samaniego MD, Schmader KE, Segev DL, Shah AS, Singer LG, Sosa JA, Stewart ZA, Tan JC, Williams WW, Zaas DW, High KP. (2012). Solid-Organ Transplantation in Older Adults: Current Status and Future Research.  Am J Transplant. 12(10):2608-22. 
  • Barnieh L, Klarenbach S, Gill JS, Caulfield T, Manns B. Attitudes Toward Strategies to Increase Organ Donation: Views of the General Public and Health Professionals. Clin J Am Soc Nephrol. 2012 Sep 27.
  • Chang P, Gill J, Dong J, Rose C, Landsberg D, Cole E, Gill JS. Minimal Impact of Living Donor Age on Kidney Allograft Half-Life: Implications for Living Donor Paired Exchange Programs. Clin J Am Soc Nephrol. 2012 May;7(5):835-41.
  • De Serres S, Varghese J, Levin A. Biomarkers in native and transplant kidneys: opportunities to improve prediction of outcomes in CKD. Current Opinion in Nephrology & Hypertension, Nov 2012; 21 (6):619-27.
  • Fairhead T, Hendren D, Tinckam K, Rose C, Sherlock C, Shi L, Crowcroft N, Landsberg D, Knoll G, Gill J, Kumar D. Poor seroprotection but allosensitization after adjuvanted pandemic influenza H1N1 vaccine in kidney transplant recipients. Transplant Infectious Disease. October 2012.
  • Gill JS, Gill J, Barnieh L, Dong J, Rose C, Johnston O, Tonelli M, Klarenbach S. Income of Living Kidney Donors and the Income Difference Between Living Kidney Donors and Their Recipients in the United States. Am J Transplant. 2012 Nov;12(11):3111-8.
  • Gill JS, Tonelli M. Penny Wise, Pound Foolish? Coverage Limits on Immunosuppression After Kidney Transplantation. New England Journal of Medicine. Published Online Feb 1, 2012.
  • Lam N, Huan A, Feldman L, Gill JS, Karpinski M, Kim J, Klarenbach S, Knoll GA, Lentine K, Nguan CY, Parikh CR, Prasad R, Treleavan DJ, Young A, Garg AX. Acute dialysis risk in living kidney donors. Nephrology, Dialysis and Transplantation Jan 30, 2012.
  • Mehrotra A, Rose C, Pannu N, Gill J, Tonelli M, Gill JS. The incidence and consequences of acute kidney injury in kidney transplant recipients. Am J Kidney Dis. 2012 Jan 4.
  • Wright L, Zaltzman JS, Gill J, Prasad GV. Kidney transplant tourism: cases from Canada. Med Health Care Philos. 2012 Nov 29. 
  • Browne S, Gill J, Dong J, Rose C, Johnston O, Zhang P, Landsberg D, Gill JS. The impact of pancreas transplantation on kidney allograft survival. Am J Transplant. 2011 Sep; 11(9):1951-8.
  • Clemens K, Boudville N, Dew MA, Geddes C, Gill JS, Jassal V, Klarenbach S, Knoll G, Muirhead N, Prasad GV, Storsley L, Treleaven D, Garg A; Donor Nephrectomy Outcomes Research (DONOR) Network. The long-term quality of life of living kidney donors: a multicenter cohort study. Am J Transplant. 2011 Mar; 11(3):463-9. 
  • Gill J, Diec O, Landsberg DN, Rose C, Johnston O, Keown PA, Gill JS. Opportunities to deter transplant tourism exist before referral for transplantation and during the workup and management of transplant candidates. Kidney Int. 2011 May; 79(9):1026-31. 
  • Gill J, Sampaio M, Gill JS, Dong J, Kuo HT, Danovitch GM, Bunnapradist S. Induction immunosuppressive therapy in the elderly kidney transplant recipient in the United States. Clin J Am Soc Nephrol. 2011 May; 6(5):1168-78.
  • Gill JS. Achieving Fairness in Access to Kidney Transplantation: A work in progress. Am J Kidney Dis. 2011 Nov; 58(5):697-9.
  • Gill JS. Managing Patients with a failed kidney transplant: how can we do better? Curr Opin Nephrol Hypertens. 2011 Nov; 20(6):616-21.
  • Günther OP, Lin D, Balshaw RF, Ng RT, Hollander Z, Wilson-McManus J, McMaster WR, McManus BM, Keown PA, Biomarkers in Transplantation Team. Effects of sample timing and treatment on gene expression in early acute renal allograft rejection. Transplantation. 2011 Feb 15;91(3):323-9.
  • Johnston O. Kidney disease: A guide for living. Book review. Am J Transplant 2011 Oct; 11(11):2532.
  • Johnston O, Cassidy H, O'Connell S, O'Riordan A, Gallagher W, Maguire PB, Wynne K, Cagney G, Ryan MP, Conlon PJ, McMorrow T. Identification of ?2-microglobulin as a urinary biomarker for chronic allograft nephropathy using proteomic methods. Proteomics Clin Appl. 2011 May 30.
  • Mammen C, White CT, Prendiville J. Childhood bullous pemphigoid: A rare manifestation of chronic renal allograft rejection. (2011). Journal of the American Academy of Dermatology. 65(1):217-9.
  • Perl J, Hasan O, Bargman JM, Jiang D, Na Y, Gill JS, Jassal SV. Impact of dialysis modality on survival after kidney transplant failure. Clin J Am Soc Nephrol. 2011 Mar; 6(3):582-90.
  • Prestidge C,Romann A, Djurdjev O, Matsuda-Abedini M. Utility and cost of a renal transplant transition clinic. Pediatric Nephrology (online ahead of print). 2011 Jul.
  • Tonelli M, Wiebe N, Knoll G, Bello A, Browne S, Jadhav D, Klarenbach S, Gill J. Systematic review: kidney transplantation compared with dialysis in clinically relevant outcomes. Am J Transplant. 2011 Oct; 11(10):2093-10
  • Young A, Hodsman AB, Boudville N, Geddes C, Gill J, Goltzman D, Jassal SV, Klarenbach S, Knoll G, Muirhead N, Prasad GV, Treleaven D, Garg AX. (2011). Donor Nephrectomy Outcomes Research (DONOR) Network Bone and Mineral Metabolism and Fibroblast Growth Factor 23 Levels After Kidney Donation. Am J Kidney Dis. 2011 Nov 15
  • Chung A, Yang HHC, Sigrist M, Chum E, Booth AD, Gourlay W, Levin A. (2010). Differential microvasculature dysfunction in living kidney donor transplant recipients: nondialyzed versus dialyzed chronic kidney disease patients. Journal of Vascular Research. 47(2):128-138.
  • Gill J, Goldberg A, Ramesh Prasad GV, Fortin MC, Hansen T, Levin A et al. (2010). Policy statement of Canadian Society of Transplantation and Canadian Society of Nephrology on organ trafficking and transplant tourism. Transplantation. 90(8):817-820.
  • Gill JS, Landsberg D, Johnston O, Shapiro RJ, Magill AB, Wu V, Tinkham K, Keown PA. Screening for de-novo anti-HLA antibodies in non-sensitized kidney transplant recipients does not predict acute rejection. Transplantation 2010;89(2):178-184. 
  • Johnston O, Jaswal D, Gill JS, Doucette S, Fergusson DA, Knoll GA. Treatment of Polyomavirus Infection in Kidney Transplant Recipients: A Systematic Review.Transplantation 2010; 89(9):1057-1070.
  • Schachter ME, Monahan M, Radakrishnan J, Crew J, Pollak M, Ratner L, Valeri AM, Stokes BM, Appel GB. (2010). Recurrent focal segmental glomerulosclerosis in the renal allograft: Single center experience in the era of modern immunosuppression. Clinical Nephrology. [Epub ahead of print]



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